Just finished reading this Pulitzer prize winning book - The Emperor of All Maladies. This is a biography about the dreaded disease cancer. Siddhartha Mukherjee is just amazing in his flow. For one continuous week, got hooked to it.
Major criticism with this book:
Of late, epigenetic phenomena such as CpG island methylation has been implicated in cancer, especially in brain tumors. Chromatin remodeling and mutations in histones (for instance, H3.3 point mutations in pediatric glioma) are being reported. Although, some of these are current discoveries, the role of epigenetics in cancer was thought about at least 3-4 years back. Siddhartha who traces cancer biography till June 2010 has not mentioned a word about these findings. Agreed that cancer is a genetic disease, but the role of these phenomena cannot be undermined.
Of late, epigenetic phenomena such as CpG island methylation has been implicated in cancer, especially in brain tumors. Chromatin remodeling and mutations in histones (for instance, H3.3 point mutations in pediatric glioma) are being reported. Although, some of these are current discoveries, the role of epigenetics in cancer was thought about at least 3-4 years back. Siddhartha who traces cancer biography till June 2010 has not mentioned a word about these findings. Agreed that cancer is a genetic disease, but the role of these phenomena cannot be undermined.
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